THE SCIENCE BEHIND ME BIOSCIENCES
PRECISION HEALTH
We are working with, learning from, and leveraging the best scientists, researchers, and technologists in the field. Recent technological advances in omics and wearable monitoring enable deep molecular and physiological profiling and will provide important tools for precision health. The time has come where we can learn how to customize what we put in and on our bodies for better health, mental health, recovery, and longevity.
Here is an example of some of the state-of-the-art research from our exciting field.
A LONGITUDINAL BIG DATA
FOR PRECISION HEALTH
NATURE MEDICINE
VOLUME 25, ISSUE 5, P792–804 | 08 MAY 2019
Precision health relies on the ability to assess disease risk at an individual level, detect early preclinical conditions and initiate preventive strategies… We explored the ability of deep longitudinal profiling to make health-related discoveries, identify clinically relevant molecular pathways and affect behavior in a prospective longitudinal cohort (n = 109) enriched for risk of type 2 diabetes mellitus. The cohort underwent integrative personalized omics profiling from samples collected quarterly for up to 8 years (median, 2.8 years) using clinical measures and emerging technologies including genome, immunome, transcriptome, proteome, metabolome, microbiome and wearable monitoring… Finally, study participation led the majority of participants to implement diet and exercise changes. Altogether, we conclude that deep longitudinal profiling can lead to actionable health discoveries and provide relevant information for precision health.
THE GUT MICROBIOTA AT THE
INTERSECTION OF DIET AND
HUMAN HEALTH
SCIENCE | VOLUME 362, ISSUE 6416, P776-780 | 16 NOV 2018
Diet affects multiple facets of human health and is inextricably linked to chronic metabolic conditions such as obesity, type 2 diabetes, and cardiovascular disease. Dietary nutrients are essential not only for human health but also for the health and survival of the trillions of microbes that reside within the human intestines. Diet is a key component of the relationship between humans and their microbial residents; gut microbes use ingested nutrients for fundamental biological processes, and the metabolic outputs of those processes may have important impacts on human physiology. Studies in humans and animal models are beginning to unravel the underpinnings of this relationship, and increasing evidence suggests that it may underlie some of the broader effects of diet on human health and disease.
PERSONALIZED NUTRITION BY
PREDICTION OF GLYCEMIC RESPONSES
CELL | VOLUME 163, ISSUE 5, P1079-1094 | 19 NOV 2015
Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary methods for controlling them have limited efficacy. Here, we continuously monitored week-long glucose levels in an 800-person cohort, measured responses to 46,898 meals, and found high variability in the response to identical meals, suggesting that universal dietary recommendations may have limited utility. We devised a machine-learning algorithm that integrates blood parameters, dietary habits, anthropometrics, physical activity, and gut microbiota measured in this cohort and showed that it accurately predicts personalized postprandial glycemic response to real-life meals. We validated these predictions in an independent 100-person cohort. Finally, a blinded randomized controlled dietary intervention based on this algorithm resulted in significantly lower postprandial responses and consistent alterations to gut microbiota configuration. Together, our results suggest that personalized diets may successfully modify elevated postprandial blood glucose and its metabolic consequences.
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